The role of the infralimbic cortex and dorsolateral striatum mediating cocaine-induced impairments in behavioral flexibility:
The infralimbic cortex and dorsolateral striatum are implicated in the formation of transition from goal-directed to habitual control of behavior....
Read More
Neurophysiological alterations in distinct corticostriatal circuits mediating behavioral flexibility in Alzheimer’s disease rat models
Alzheimer's disease is characterized by memory-loss, however, other cognitive symptoms often precede these deficits including cognitive flexibility and decision-making. In...
Read More
GABAergic signaling in the prelimbic cortex and infralimbic cortex to natural reward cues vs drug cues.
Substance use disorders (SUDs) are associated with cycles of drug use, abstinence, and relapse. A history of SUDs leads to...
Read More
Techniques
The West Lab utilizes a multitude of techniques to probe circuit level function and dysfunction in neuropsychiatric and neurodegenerative disorders including in vivo electrophysiology (Plexon), Ca++ imaging (Inscopix), optogenetics, chemogenetics, and behavioral and cognitive tasks in awake and behaving rats.
