The infralimbic cortex and dorsolateral striatum are implicated in the formation of transition from goal-directed to habitual control of behavior. […]
West LAB
The goals of the West Lab are to:
1) identify the neurobiological mechanisms that underlie learning, decision-making and cognitive flexibility,
2) elucidate how these neural circuits are altered in animal models, and
3) restore function to these circuits with the aim of improving decision-making in disease states.
To achieve these aims, we utilize state-of-the-art in vivo recording techniques including in vivo electrophysiology and optical imaging (cellular Ca++ imaging) to characterize neural circuits necessary for learning and decision-making in awake behaving rats. We also employ optogenetic, chemogenetic, and pharmacological manipulations to assess causality at the circuit level. Finally, we aim to develop and test potential treatment strategies, such as non-invasive brain stimulation, to restore decision-making deficits in relevant models of neuropsychiatric and neurodegenerative diseases.
Projects
Neurophysiological alterations in distinct corticostriatal circuits mediating behavioral flexibility in Alzheimer’s disease rat models
Alzheimer’s disease is characterized by memory-loss, however, other cognitive symptoms often precede these deficits including cognitive flexibility and decision-making. In […]
GABAergic signaling in the prelimbic cortex and infralimbic cortex to natural reward cues vs drug cues.
Substance use disorders (SUDs) are associated with cycles of drug use, abstinence, and relapse. A history of SUDs leads to […]
