Neurophysiological alterations in distinct corticostriatal circuits mediating behavioral flexibility in Alzheimer’s disease rat models 


Alzheimer’s disease is characterized by memory-loss, however, other cognitive symptoms often precede these deficits including cognitive flexibility and decision-making. In this project we will use in vivo electrophysiology to determine how the prelimbic/nucleus accumbens and infralimbic/dorsolateral striatum circuits are altered during learning and flexible behavior in rats developed to recapitulate Alzheimer’s disease pathology.

Funded by NIA, R00DA042934-03S1